Who we are

The main objective of my group is to augment our understanding on the molecular mechanisms that underlie and control vital cellular functions. We approach this challenge by deciphering the dynamic interplay between the function and spatiotemporal localization of biomolecules (virus, dug nanocarrier, oligonucleotides or protein assemblies) and how this correlate to cellular and organismal response. We utilize an eclectic mix of single particle techniques that promises to shed light on the interplays between the behaviour (dynamics, function and localisation) of biomolecules and high throughput single particle screening methodologies to decipher oligonucleotide interactions with membranes.
Recognizing that 4D imaging generates terabytes of data sets, that are hard to be quantitatively evaluated by current semi-manual analysis, we have developed toolboxes based on machine learning to rapidly and reliably, analyze the wealth of novel microscopy data we, and others, produce. Our all-inclusive softwares for windows and macs, offer accelerate by 5 orders of magnitude transition from raw data to quantitative analysis. These combined methodologies bridge 4D imaging with sophisticate image analysis required for delving into the era of 4D cell and tissue imaging.